急性低压缺氧对飞行员血浆超氧化物歧化酶及总抗氧化能力的影响

目的：探讨急性低压缺氧对飞行员血浆铜锌超氧化物歧化酶（CuZn-SOD)及总抗氧化能力（T－AOC）的影响。方法：用比色法测定了16名健康男性歼击机飞行员缺氧前（6：00）、急性中度低压缺氧后即刻（10：00）及6h后（16：00）的血浆CuZn-SOD水平及T－AOC,并以16名健康男性地面人员相应时间的测定作对照。结果：缺氧前飞行员的基础CuZn-SOD水平高于对照组（P＜0．05）;缺氧后即刻,飞行员的血浆CuZn-SOD水平较缺氧前明显降低（P＜0．05）,缺氧结束后6h恢复到缺氧前水平;缺氧后即刻血浆T－AOC显著低于缺氧前（P＜0．05）,缺氧后6h亦恢复到缺氧前水平。结论：急性中度低压缺氧可使飞行人员发生短暂的血浆CuZn-SOD水平下降,T－AOC降低,应使飞行员充分了解可能发生缺氧的原因,辨认缺氧症状,及时纠正。

Effect of acute hypoxia on plasma super oxide dismutas and total antioxidant capacity in pilots

Objective To explore the effect of acute hypoxia on plasma superoxide dismutas(SOD) content and total antioxidant capacity(T-AOC ) in pilots. Methods Sixteen healthy pilots served as subject s. The plasma levels of SOD and T-AOC were measured by colorimetry before moder ate hypoxic exposure (6:00 am), after exposure (10:00 am) and 6 h later. Sixteen ground served as controls. They did not undergo hypoxic exposure and their plas ma SOD and T-AOC levels were assayed at corresponding time. Result The baseline plasma Cu Zn-SOD level was significantly higher than that of controls (P<0.05). The plasma Cu Zn-SOD level immediately after hypoxic wa s significantly lower than baseline level, and return to baseline level 6 h late r. The plasma T-AOC level immediately after hypoxic exposure was significantly lower than baseline level, and return to original level 6 h later. Conc lusion Moderate hypoxia can induce temporary decrease of plasma SOD and T-AOC. Aircrew must be fully aware of causes of hypoxia incidents and how to r ecognize the condition on correct it when it occurs.