| 正交设计法优选解毒通络颗粒提取工艺 |
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| 引用本文： | 韩忠耀,周福军,单淇,刘时乔,侯文彬. 正交设计法优选解毒通络颗粒提取工艺[J]. 中国实验方剂学杂志, 2012, 18(9): 13-16 |
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| 作者姓名： | 韩忠耀 周福军 单淇 刘时乔 侯文彬 |
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| 作者单位： | 1. 天津中医药大学,天津,300193
2. 天津药物研究院,天津,300193 |
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| 基金项目： | 国家十一五重大新药专项(2009ZX09103-310) |
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| 摘 要： | 目的:正交试验法优选解毒通络颗粒处方药材的提取工艺.方法:以出膏率、丹酚酸B及天麻素为考核指标,采用L9(34)正交试验考察解毒通络颗粒处方药材提取工艺条件.结果:解毒通络颗粒处方药材的最佳提取工艺为10倍量70％乙醇提取3次,每次提取1.5h.结论:该提取工艺稳定可行,省时、省工、节能,适合于工业化大生产,为解毒通络颗粒的制剂研究奠定基础.
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| 关 键 词： | 解毒通络颗粒 正交设计 提取工艺 高效液相色谱法 |
| 收稿时间： | 2011-12-19 |
Optimization of Extraction Process of Jiedu Tongluo Granule by Orthogonal Design |
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| HAN Zhong-yao,ZHOU Fu-jun,SHAN Qi,LIU Shi-qiao and HOU Wen-bin. Optimization of Extraction Process of Jiedu Tongluo Granule by Orthogonal Design[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2012, 18(9): 13-16 |
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| Authors: | HAN Zhong-yao ZHOU Fu-jun SHAN Qi LIU Shi-qiao HOU Wen-bin |
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| Affiliation: | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | Objective: To optimize extraction process of prescription drugs from Jiedu Tongluo granule by orthogonal test. Method: With extract rate, salvianolic acid B and gastrodin as indexes,extraction technology conditions of Jiedu Tongluo granule was investigated by L9(34) orthogonal test method. Result: Optimum extraction technology was:extracted 3 times with 1.5 h each time by 10 times the amount of 70% ethanol. Conclusion: This optimized extraction technology was stable,feasible.Meanwhile,it could save time,labor and energy and be suitable for industrial mass production,it could settle foundation for preparation of Jiedu Tongluo granule. |
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| Keywords: | Jiedu Tongluo granule orthogonal design extraction technology HPLC |
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