中药来源醛糖还原酶抑制剂的研究进展

醛糖还原酶抑制剂是治疗糖尿病并发症的重要药物之一，可通过抑制体内高血糖状态下被激活的多元醇通路中醛糖还原酶的活性而减少山梨醇的蓄积，预防和延缓糖尿病及其并发症的发生发展。中药来源的醛糖还原酶抑制剂来源更加广泛，显示了良好的应用前景。综述了2010—2020年报道的来源于中药的醛糖还原酶抑制剂及其在改善糖尿病并发症症状等方面取得的研究进展，主要包括生物碱类、黄酮类、酚酸类、皂苷类、多糖类，以及中药提取物，以期为新药研发提供依据。

Research progress of aldose reductase inhibitors derived from traditional Chinese medicine

Aldose reductase inhibitors are one of the important drugs for the treatment of diabetic complications, which can reduce the accumulation of sorbitol by inhibiting aldose reductase in the polyol pathway activated under the condition of hyperglycemia in the body, and prevent and delay the occurrence and development of diabetes and its complications. Aldose reductase inhibitors derived from traditional Chinese medicine are more widely available, which shows a good application prospect. The aldose reductase inhibitors derived from traditional Chinese medicine and their research progress in improving the symptoms of diabetes complications from 2010 to 2020 are reviewed in order to provide the basis for the research and development of new drugs. The aldose reductase inhibitors in this review mainly include alkaloids, flavonoids, phenolic acids, saponins, polysaccharides and several herbal extracts.