|
|||||
|
|
| 血卟啉衍生物（HPD）在肿瘤和正常组织中的分布及细胞内定位 | |
| 引用本文： | 唐建武 朱逢春. 血卟啉衍生物（HPD）在肿瘤和正常组织中的分布及细胞内定位[J]. 中国肿瘤临床, 1993, 20(12): 934-936 |
| 作者姓名： | 唐建武 朱逢春 |
| 作者单位： | 大连医学院，大连医学院，大连医学院 大连市 116023，大连市 116023，大连市 116023 |
| 摘 要： | 荧光分光光度分析和荧光显微镜观察表明，腹腔给药后２４－７２小时，荷瘤机体瘤组织中ＨＰＤ含量高于肝，肾，肺及肌肉，给药后２４－４８小时和４８－７２小时的ＨＰＤ清除速率以肿瘤组织最低，ＨＰＤ荧光主要位于肿瘤细胞浆内，少量位于细胞核。 |
| 关 键 词： | 血卟啉衍生物 分光光度法 肿瘤 |
Distribution of Hematoporphyrin Derivative in Tumor and Normal Tissues and Localization of HPD in Tumor Cells |
|
| Tang Jian-Wu al Dalian Medical College,Dalian. Distribution of Hematoporphyrin Derivative in Tumor and Normal Tissues and Localization of HPD in Tumor Cells[J]. Chinese Journal of Clinical Oncology, 1993, 20(12): 934-936 | |
| Authors: | Tang Jian-Wu al Dalian Medical College Dalian |
| Abstract: | The contents of hematoporphyrin derivative (HPD) in tumor and other tissues in mice were determined using spectrophotofluorometry and fluorescence microscopy. The results showed that the content in tumor was higher than those in liver, kidney, lung and muscles from 24 to 72 hours after injection of HPD intraperitoneally. The clearance of HPD in tumor tissue was the lowest from 24 to 72 hours after injection when compared with those in other tissues. The fluorescence of HPD was observed densely in cytoplasm of tumor cells and faintly in nuclei. |
| Keywords: | Hematoporphyrin derivative (HPD) Spectrophotofluorometry Fluorescence microscopy |
| 本文献已被 CNKI 维普 等数据库收录！ | |