甘精胰岛素联合阿卡波糖治疗2型糖尿病效果观察

目的探讨甘精胰岛素联合阿卡波糖治疗2型糖尿病的临床效果。方法将86例2型糖尿病患者随机分为两组,各43例。对照组给予诺和锐30联合阿卡波糖治疗,观察组给予甘精胰岛素联合阿卡波糖治疗。治疗3个月后,观察两组临床疗效及低血糖事件发生率,治疗前后空腹血糖（FBG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（Hb A1c）及超敏C反应蛋白（hs-CRP）指标。结果观察组患者有效率为88.37%,对照组为83.72%,两组有效率比较差异无统计学意义（P〉0.05）;观察组低血糖事件发生率为2.33%,低于对照组的18.60%（P〈0.05）。治疗前两组FBG、2 h PG、Hb A1c及hs-CRP比较差异均无统计学意义（P〉0.05）;治疗3个月后,除对照组hs-CRP外,两组上述指标均有明显下降;两组治疗后比较,观察组FBG低于对照组（P〈0.01）,其他指标两组差异均无统计学意义（P〉0.05）。结论甘精胰岛素联合阿卡波糖治疗2型糖尿病效果显著,可有效降低低血糖事件发生率,平稳降糖,值得临床推广应用。

Comparison of the curative effect of insulin glargine and aspart 30 combined with acarbose in treatment of type 2 diabetes mellitus

Objective To study the clinical effects of insulin glargine and aspart 30 combined with acarbose in treatment of Ⅱ diabetes mellitus as well as the hypoglycemia occurrence rate .Methods Eighty-six cases of poorly-controlled Ⅱ diabetes patients were randomly divided into two groups ,with 43 cases in each group.The contrast group took the treatment of insulin glargine combined with acarbose and the observation group took the medication of aspart 30 combined with acarbose.Clinical effects of the two groups ,hypogly-cemia occurrence rate during treatment ,fasting blood glucose （FBG）,2 h postprandial blood glucose （2 h PG）,glycosylated hemoglo-bin （HbAlc） and high sensitive C reactive protein （hs-CRP） were observed 3 months after treatment.Results Observation group’s efficiency rate was 88.37%; contrast group’s efficiency rate was 83.72%; there was no statistically significant difference （ P 〉0.05） in the two groups.The hypoglycemia occurrence rate in observation group was 2.33%,which was lower than 18.60% of contrast group （ P 〈0.05）.FBG,2 h PG,HbAlc and hs-CRP of the two groups before treatment showed no significant difference （ P 〉0.05）,but 3 months after treatment except for hs -CRP of the contrast group, the above indexes of the two groups decreased significantly and FBG was lower than that of the control group after treatment （ P 〈0.01）,but there was no statistically significant difference between the oth -er indexes of the two groups（ P 〉0.05）.Conclusion The treatment effect of insulin glargine combined with acarbose for Ⅱ diabetes mellitus patient is satisfactory and can lower the occurrence rate of hypoglycemia and reduce blood glucose steadily .