血清降钙素原检测在慢性阻塞性肺疾病急性加重期治疗中的应用价值

目的探讨血清降钙素原（PCT）检测在慢性阻塞性肺疾病急性加重期（AECOPD）治疗中的应用价值。方法将90例AECOPD患者随机分为两组,各45例。观察组根据PCT检测指标给予抗生素治疗,对照组根据超敏C反应蛋白（hsCRP）和（或）白细胞（WBC）指标给予抗生素治疗,观察两组治疗前及治疗8 d后PCT、hs-CRP及WBC指标变化,以及抗生素使用时间、住院时间及治疗效果等。结果治疗8 d后,两组PCT、hs-CRP及WBC指标均较治疗前明显下降（P〈0.01）,且观察组PCT水平低于对照组（P〈0.01）;观察组抗生素使用时间及住院时间均短于对照组（P〈0.05或P〈0.01）。结论PCT检测对AECOPD抗生素的使用具有较高的临床指导价值,可规范抗生素的合理应用,缩短抗生素的使用时间以及患者的住院时间。

The application value of serum procalcitonin on the chronic obstructive pulmonary disease in acute exacerbation period

Objective To investigate the clinical value of the serum procalcitonin （PCT） in chronic obstructive pulmonary disease with acute exacerbation （AECOPD）.Methods Nitety AECOPD patients were randomly divided into two groups with 45 cases in each group.The observation group was given antibiotic treatment according to the levels of PCT .The control group was given guided treatment on the basis of high sensitivity C reactive protein （hs-CRP） and （or） white blood cell （WBC） level.For both groups,PCT, hs-CRP and WBC and detailed records of time of the use of antibiotics ,hospitalization time and treatment efficacy before treatment and eight day after treatment were observed.Results On 8 d after treatment,the levels of PCT, hs-CRP,WBC,and hospitalization time were much lower than that before treatment （ P 〈0.01）.PCT level of the observation group was lower than that of the control group （P 〈0.01）,but the time of use of antibiotics and hospitalization time were shorter than that of control group （ P 〈0.05 or P 〈0.01）.Conclusion PCT Monitoring has higher clinical value for the use of AECOPD antibiotics and can guide the antibiotic applica -tion,standardize the reasonable application of antibiotics , reduce the time of use of antibiotics and hospitalization time .