| 氧氟沙星片相对生物利用度实验研究 |
| |
| 引用本文： | 黄林清 徐传福. 氧氟沙星片相对生物利用度实验研究[J]. 华西药学杂志, 1997, 12(4): 237-237 |
| |
| 作者姓名： | 黄林清 徐传福 |
| |
| 作者单位： | 第三军医大学附属新桥医院临床药理基地!重庆，630037，第三军医大学附属新桥医院临床药理基地!重庆，630037，第三军医大学附属新桥医院临床药理基地!重庆，630037，第三军医大学附属新桥医院临床药理基地!重庆，630037，第三军医大学附属新桥医院临床药理基地!重庆，630037 |
| |
| 摘 要： | 用离子对反相高效液相色谱法测定人体血浆中氧氟沙星的浓度。以北京制药厂生产的氧氟沙星片为参照标准，随机交叉设计，考察了湖南省岳阳市制药二厂生产的氧氟沙星片的相对生物利用度。８名健康志愿受试者分别口服单剂量两药厂生产的氧氟沙星片（３００ｍｇ）后，从吸收、分布、排汇上其药物动力学参数均无显著差异（Ｐ〉０．０５，配对ｔ－ｔｅｓｔ），其相对生物利用度为１０５％。
|
| 关 键 词： | 氧氟沙星 相对生物利用度 高效液相色谱法 |
RELATIVE BIOAVAILABILITY OF OFLOXACIN TABLET |
| |
| Huang Linqing, Xu Chuanfu, Zhou Shiwen, Zhang Shiping, Li Yonglai. RELATIVE BIOAVAILABILITY OF OFLOXACIN TABLET[J]. West China Journal of Pharmaceutical Sciences, 1997, 12(4): 237-237 |
| |
| Authors: | Huang Linqing Xu Chuanfu Zhou Shiwen Zhang Shiping Li Yonglai |
| |
| Abstract: | Plasma level of Ofloxacin was determined by ion-pair-RP-HPLC with flurometeric detector. The relative bioavailability of Ofloxacin tablet produced by Yueyang No. 2 pharmaceutical factory was studied in eight normal volunteers. A single oral dose of 300mg of Ofloxacin tablets made in Yueyang No. 2 pharmaceutial factory and Beijing pharmaceutical factory was given respectively according toa cross-over design. Pharmacokinectic parameters obtained from our studies showed no significant difference between the two products. The relative bioavailability of ofloxacin made in Yueyang No. 2 pharmaceutical factory was 105%. |
| |
| Keywords: | Ofloxacin Relative bioavaiability HPLC |
| 本文献已被 CNKI 维普 等数据库收录！ |
