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| EGFR表达位置在胃癌发生中的意义 | |
| 引用本文： | 李 梅,刘丽娜,王朝晖,冯 璐,李雅楠,张秋萍.EGFR表达位置在胃癌发生中的意义[J].大连医科大学学报,2010,32(2):170-172. |
| 作者姓名： | 李 梅 刘丽娜 王朝晖 冯 璐 李雅楠 张秋萍 |
| 作者单位： | 1. 大连医科大学附属第二医院,实验中心,辽宁,大连,116027 2. 大连医科大学附属第一医院,消化内科,辽宁,大连,116011 3. 大连医科大学附属第一医院,病理科,辽宁,大连,116011 |
| 摘 要： | 目的]探讨肿瘤细胞中EGFR表达位置改变与胃癌发生的关系及其意义。方法]免疫组织化学方法检测非癌胃黏膜、胃癌组织EGFR、Ki67表达。结果]非癌胃黏膜组和胃癌组,EGFR阳性表达率分别为76.5%和74.2%,二者差异无显著性意义;EGFR细胞膜表达率分别为92.3%和52.2%,非癌胃黏膜组显著高于胃癌组(P=0.001)。非癌胃黏膜组和胃癌组Ki67阳性表达率分别为48.4%和77.3%,非癌胃黏膜组Ki67表达率显著低于胃癌组(P=0.010)。非癌胃黏膜组EGFR细胞膜表达与Ki67阳性表达正相关(P=0.054),EGFR细胞浆表达与Ki67阳性表达无明显相关关系(P=0.484);胃癌组EGFR细胞膜表达、细胞浆表达与Ki67表达均无明显相关关系(P=0.287;P=0.724)。EGFR细胞浆表达与胃癌分化程度显著正相关(P=0.030)。结论]胃癌细胞增殖常出现EGFR的胞浆堆积。 |
| 关 键 词： | 胃肿瘤 表皮生长因子受体 Ki67 |
Significance of the sites of EGFR expressions in gastric carcinogenesis |
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| LI Mei,LIU Li-n,WANG Zhao-hui,FENG Lu,LI Ya-nan and ZHANG Qiu-ping.Significance of the sites of EGFR expressions in gastric carcinogenesis[J].Journal of Dalian Medical University,2010,32(2):170-172. | |
| Authors: | LI Mei LIU Li-n WANG Zhao-hui FENG Lu LI Ya-nan and ZHANG Qiu-ping |
| Institution: | 1.Laboratory Center;the Second Affiliated Hospital of Dalian Medical University;Dalian 116027;China;2.Department of Gastroenterology;3.Department of Pathology;the First Affiliated Hospital of Dalian Medical University;Dalian 116011;China |
| Abstract: | Objective]To explore the significance and the relationship between the site changes of EGFR expression in cancer cells and gastric carcinogenesis.Methods]EGFR and Ki67 expressions in gastric mucosas and carcinomas were detected by immunohistochemistry.Results]Between gastric mucosa group and carcinoma group,there was no significant difference in the frequencies of EGFR expression(76.5% and 74.2%,respectively),but the frequency of EGFR expression in cytomembrane were significantly higher in the former tha... |
| Keywords: | gastric cancer EGFR Ki67 |
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