表皮生长因子受体在食管癌中的表达及临床意义

目的探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)与食管癌临床病理特征及预后的关系。方法采用免疫组织化学法检测92份食管癌组织,26份Ⅰ度不典型增生组织,17份Ⅱ/Ⅲ度不典型增生组织,89份正常食管黏膜组织(正常组)的EGFR表达情况,并分析EGFR与临床组织病理特征及预后的关系。结果正常组、Ⅰ度不典型增生组、Ⅱ/Ⅲ度不典型增生组、食管癌组中EGFR过表达率分别为0(0/89),19.23%(5/26),58.82%(10/17),69.57%(64/92);EGFR过表达在不同浸润深度,是否伴淋巴结转移上差异均有统计学意义(P<0.05);EGFR过表达阳性组与阴性组生存曲线差异有统计学意义(P<0.05)。结论 EGFR过表达与食管癌发生、发展及预后密切相关。

Expression of EGFR in patients with esophageal cancer and its clinical significance

Objective To study the relationship of epidermal growth factor receptor(EGFR) with clinicopathological features and prognosis of esophageal cancer.Methods The immunohistochemistry method was used to test the expression of EGFR in 89 cases of esophageal normal tissue,26 cases of esophageal dysplasia tissue degree Ⅰ,17 cases of esophageal dysplasia tissue degree Ⅱ/Ⅲ and 92 cases of esophageal cancer tissue.The testing results were analyzed and compared with the clinicopathological features and prognosis.Results Overexpression rate of EGFR was 0(0/89),19.23%(5/26),58.82%(10/17) and 69.57%(64/92) in normal tissue,dysplasia degrees I group,dysplasia degrees Ⅱ/Ⅲ group and esophageal cancer group respectively,which showed significant differences between each two groups(P<0.05).The overexpression of EGFR in esophageal cancer tissues showed significant differences in different infiltration depths and between patients with and without lymph node metastasis(P<0.05).There was a significant difference in survival curves between the patients with positive and negative overexpression of EGFR(P<0.05).Conclusion The overexpression of EGFR is closely correlated with the occurrence,development and prognosis of esophageal cancer.