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Antibacterial activity of hydroxychalcone against methicillin-resistant Staphylococcus aureus |
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| Authors: | Sato M Tsuchiya H Miyazaki T Fujiwara S Yamaguchi R Kureshiro H Iinuma M |
| Affiliation: | a Department of Oral Microbiology, Asahi University School of Dentistry, 1851 Hozumi, Hozumi-cho, Motosu-gun, Gifu 501-02, Japan b Department of Dental Pharmacology, Asahi University School of Dentistry, Gifu 501-02, Japan c Department of Prosthetic Dentistry, Asahi University School of Dentistry, Gifu 501-02, Japan d Institute of Radio Isotope, Asahi University School of Dentistry, Gifu 501-02, Japan e Department of Pharmacognocy, Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5 chome, Gifu 502, Japan |
| Abstract: | Anti-candidal hydroxychalcone, 2,4,2′-trihydroxy-5′-methylchalcone (THMC), was investigated for its antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). THMC showed the minimum inhibitory concentrations of 25.0–50.0 μg/ml against tested 20 strains, at which the effect was based on a bacteriostatic action. THMC of 25.0 μg/ml completely inhibited the incorporation of radio-labelled thymidine and uridine into MRSA cells. In combination with antibiotics, the fractional inhibitory concentration indices were 0.47 for gentamicin and 0.79 for vancomycin, indicating that THMC acts synergistically with these agents. THMC would be a potent therapeutic agent for MRSA infections. |
| Keywords: | Hydroxychalcone Methicillin-resistant Staphylococcus aureus (MRSA) Antibacterial activity Fractional inhibitory concentration (FIC) index |
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