甲亢患者外周血白细胞及其VCS参数观察

目的分析甲状腺功能亢进症（甲亢）患者外周血白细胞数量及其VCS变化。方法以LH750全自动血细胞分析仪对60例甲亢患者外周血自细胞检测，比较白细胞及其分类的数量变化；同时进行VCS参数的数据分析。结果60例甲亢患者单核细胞相对计数和单核细胞绝对计数分别为（9．0±3．1）％、（4．8±1．9）×10^8／L，均高于对照组的（6．5±2．3）％、（3．6±1．2）×10^8／L，两组之间差别显著（P〈0．01）。甲亢患者具有LMR、中性粒细胞V-均值、淋巴细胞C-均值均降低的特征。LMR的敏感性和特异性分别为72．7％、50．8％（cutoff值=4．0）。中性粒细胞V-均值、淋巴细胞C-均值对甲亢的诊断具有较高的敏感度（ROC下面积分别为0．629、0．706）。结论甲亢患者外周血单核细胞数量上升，LMR比值降低，白细胞VCS参数有助于临床上甲亢的诊断。

Changes of leukocyte and its VCS parameters in peripheral blood of hyperthyroidism patients

Objective To analyze the changes of leukocyte and its VCS parameters in peripheral blood of hyperthyroidism patients. Methods Leukocyte in peripheral blood of 60 hyperthyroidism patients were detected by using Beckman Coulter LH750 hematology analyzer, meanwhile classification and VCS parameters of leukocyte were analyzed. Results The relative and absolute counting of monocytes in 60 hyperthyroidism patients were(9.0 ±3.1)% 、(4.8 ± 1.9) × 108/L respectively,which were significantly higher than those of healthy eontrols(P ＜0.01 ). LMR,neutrophil V means and lymphocyte C means were decreased in hyperthyroidism patients. The sensitivity and specificity of LMR were 72.7% ,50.8% ( cutoff = 4.0) respectively. Neutrophil V means and lymphocyte C means showed a high sensitivity for the diagnosis of hyperthyroidism ( areas under the ROC curves were 0.629、0.706 respectively). Conclusion An increased monocytes and a decreased LMR ration were found in hyperthyroidism patients, which made leukocyte and its VCS parameters contribute to diagnose of hyperthyroidism.