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| 新型抗心绞痛药物雷诺嗪的合成工艺改进 | |
| 引用本文： | 王海琴,朱航昌,陈国华. 新型抗心绞痛药物雷诺嗪的合成工艺改进[J]. 药学与临床研究, 2007, 15(4): 282-284 |
| 作者姓名： | 王海琴 朱航昌 陈国华 |
| 作者单位： | 中国药科大学药化实验室,南京,210009;中国药科大学药化实验室,南京,210009;中国药科大学药化实验室,南京,210009 |
| 摘 要： | 目的:对抗心绞痛药雷诺嗪现有合成工艺进行改进.方法:以2,6-二甲基苯胺为起始原料,经过酰化、缩合、环加成、成盐等4步反应合成产品雷诺嗪.结果:产品总收率为51.9%,其化学结构经1H NMR、MS、IR确证,HPLC法检测纯度达到99.2%.结论:该工艺反应条件温和,收率较高,操作简便,易于工业化生产. |
| 关 键 词： | 雷诺嗪 合成 工艺改进 |
| 文章编号： | 1673-7806（2007）04-282-03 |
| 收稿时间： | 2007-04-24 |
| 修稿时间： | 2007-04-24 |
Improved synthesis of a novel antianginal agent ranolazine |
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| WANG Hai-qin,ZHU Hang-chang and CHEN Guo-hua. Improved synthesis of a novel antianginal agent ranolazine[J]. Pharmacertical and Clinical Research, 2007, 15(4): 282-284 | |
| Authors: | WANG Hai-qin ZHU Hang-chang CHEN Guo-hua |
| Affiliation: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
| Abstract: | Objective:The purpose is to improve the general synthesis process of antianginal agent ranolazine. Methods: It was synthesized from 2,6-dimethylaniline, via four-step reaction with acylation, condensation, cycloaddition, saltify. Results: The target compound was synthesized successfully with 51.9% overall yield and its chemical structure was confirmed by 1H-NMR, MS and IR. The purity is more than 99% detected by HPLC. Conclusion: The procedure has the advantages of milder reaction conditions, higher yield with relatively simple operation procedure and easily to be industrial manufactured. |
| Keywords: | Ranolazine Synthesis Improvement relatively simple |
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