育龄妇女维生素D缺乏与弓形虫感染的关联

目的探讨育龄妇女维生素D缺乏风险与弓形虫感染的关系。方法 2007—2010年,在河南省4个县开展育龄妇女围孕期风险因素暴露调查,采用多阶段随机抽样方法,建立育龄妇女孕前风险因素暴露的前瞻性队列,采用酶联免疫吸附法(ELISA)检测血清弓形虫抗体。2016年随访到有妊娠结局的妇女1151例,并测量该人群孕前血清标本中的维生素D水平。采用病例-对照研究方法,检验维生素D缺乏风险与弓形虫感染之间的关联。结果河南省育龄妇女维生素D缺乏率为61.5%(95%CI 59.2%～64.9%),弓形虫感染阳性率为9.6%(95%CI 7.9%～11.4%),其中IgG阳性、IgM阳性和两者均阳性者分别为7.6%、2.3%和0.3%。调整妇女教育程度、家庭年收入、食用禽蛋类和奶制品后发现,感染弓形虫的妇女维生素D缺乏的危险是未感染妇女的1.75倍(95%CI 1.11～2.77)。结论育龄妇女孕前感染弓形虫与其维生素D缺乏的风险存在关联。

Association between vitamin D deficiency and Toxoplasma gondii infection in women of childbearing age

OBJECTIVE To explore the association between the risk of vitamin D deficiency and the infection of Toxoplasma gondii in women of childbearing age.METHODS Based on a Women’s Reproductive Health Cohort Study performed from 2007 to 2010 in four counties of Henan Province,Toxoplasma gondii infection were tested by enzyme linked immunosorbent assay(ELISA).A total of 1151 women with pregnancy outcomes were followed up and pre-pregnancy vitamin D level was measured with serum samples.Case-control study was used to examine the association between the risk of vitamin D deficiency and Toxoplasma infection.RESULTS The prevalence of vitamin D deficiency was 61.5%(95%CI 59.2%-64.9%)and Toxoplasma infection was 9.6%(95%CI 7.9%-11.4%),among which IgG positive,IgM positive and both positive were 7.6%,2.3%and 0.3%,respectively.After adjusting confounding factors,including education,family annual income,and dietary intake frequencies.,it was found that the risk of vitamin D deficiency in women infected with Toxoplasma gondii recently or previously was 1.75 times higher than that of uninfected women(95%CI 1.11-2.77).CONCLUSION There is association between the risk of vitamin D deficiency and the infection of Toxoplasma gondii in women of childbearing age.