急性胰腺炎患者空腹高血糖发生率及其危险因素分析

目的:回顾性分析急性胰腺炎(AP)患者空腹高血糖发生率及其危险因素。方法:收集2018-01—2018-12武汉大学人民医院胰腺外科133例AP且无糖尿病(DM)病史的住院患者病历资料,按照不同性别、年龄、AP临床分型、病因、CT指数评分(CISI)等分组,χ2检验分析各组临床因素与空腹高血糖(FPG≥6.1mmol/L)发生率的关系,多因素二元logistic回归分析空腹高血糖独立危险因素。结果:AP临床分型(χ2=5.494,P=0.019)和CTSI(χ2=6.236,P=0.013)与AP患者空腹高血糖相关(P<0.05)。CTSI≥6分(P=0.015,OR=2.920,95%Cl=1.234—6.905)为AP患者空腹高血糖的独立危险因素(P<0.05)。结论:临床分型中重症+重症及CTSI≥6分的AP患者易发生空腹高血糖,尤其CTSI≥6分是AP后空腹高血糖的独立危险因素,临床应高度关注。

Incidence and Risk Factors of Fasting Hyperglycemia in Patients with Acute Pancreatitis

Objective:To investigate the incidence and risk factors of fasting hyperglycemia in patients with acute pancreatitis(AP).Method:Data of 133 patients with AP and no previous history of diabetes treated in Renmin Hospital of Wuhan University were collected.The clinical characteristics were compared according to gender,age,AP clinical classification,etiology and CTSI score.The incidence of fasting hyperglycemia(FPG≥6.1mmol/L)was calculated based on FPG at discharge.Chi-square test and multivariate regression were performed to analyze the relationship between patient data and fasting hyperglycemia.Results:Chi-square test showed severity grading of AP(χ2=5.494,P=0.019)and CTSI score(χ2=6.236,P=0.013)were associated with fasting hyperglycemia in AP patients(P<0.05).Logistic multivariate regression analysis showed that CTSI score≥6(P=0.015,OR=2.920,95%Cl=1.234—6.905)was an independent risk factor of fasting hyperglycemia in AP patients(P<0.05).Conclusion:Severity grading of AP and CTSI score were correlated with fasting hyperglycemia in AP patients,among which CTSI score≥6 was classified as independent risk factor.