短期胰岛素强化治疗应激性高血糖的临床研究

目的探讨短期胰岛素强化治疗（SCIIT）对应激性高血糖患者近期临床结局的影响。方法采用随机对照临床试验,在排除影响糖代谢的疾病条件下,将120例随机血糖〉11.1mmol/L,入住ICU的重症患者随机分为短期强化治疗组（IIT组,n=60）和传统胰岛素治疗组（CIT组,n=58）,治疗组在纳入研究的前7d,严格控制血糖于4.4～6.1mmol/L,此后的血糖控制及其他处理均同对照组。对照组患者的血糖控制在3.9～10mmol/L。结果入选病例120例,118例纳入研究,在停止胰岛素强化治疗20d内,治疗组平均血糖为（5.92±1.24）mmol/L,明显较对照组（9.22±2.51）mmol/L低,强化治疗后每天胰岛素用量明显比对照组低;ICU停留时间明显缩短,院内感染发生率降低,两组30d病死率无明显差异。结论采用短期胰岛素强化治疗方案可以改善重症患者的近期临床结局。

Clinical study of short-corse intensive insulin therapy on stress-induced hyperglycemia patients

Objective To investigate the effect of short course intensive insulin therapy(SCIIT)on stress-induced hyperglycemia and outcomes in critically ill patients. Methods We excluded all the illness that may directly influenced blood glucose and the critically ill patients were maintained with normoglycemia of 4.4~6.1 mmol/L in the first seven days receiving intensive insulin therapy. Conventional insulin treatment group were maintained with blood glucose at a level between 3.9~10 mmol/L. After the first seven da...