同型半胱氨酸与脑梗死关系探讨

目的　探讨血清总同型半胱氨酸 (tHcy)水平与脑梗死关系。方法　测定 112例脑梗死患者及 4 2例健康对照者的血清总同型半胱氨酸 (tHcy)、维生素B12 (VitB12 )和叶酸 (FA)水平。结果　 ( 1)脑梗死组的血清tHcy平均水平 ( 17 10± 8 5 3) μmol/L显著高于对照组 ( 11 18± 3 0 2 ) μmol/L ;( 2 )血清tHcy水平与FA与VitB12 水平均呈负相关 ;( 3)高同型半胱氨酸血症 (Hcy >15 0 μmol/L) ,经校正性别、年龄、吸烟、血脂、血压、血糖等危险因素后 ,脑梗死的相对危险度 (OR)为 4 78,95 %可信区间 (CI)为 1 70～ 13 4 6 ]。结论　 ( 1)血清tHcy水平升高可增加脑梗死的发病危险度 ;( 2 )FA、VitB12 是tHcy的非遗传影响因素。

To Explore the Relationship between Serum Homocysteine Concentration and Cerebral Infarction

Objective To explore the relationship between Serum Homocysteine(Hcy) concentration and cerebral infarction. Methods Serum Hcy,Vitamin B 12 and folic acid (FA) levels were determined in 112 patients with cerebral infarction and 42 healthy controls. Results (1)The level of serum Hcy was markedly higher in cerebral infarction patients than that in control group (17 10±8 53μmol/L Vs 11 18±3 02μmol/L).(2)Hcy level was significantly negatively correlated with both vitamin B 12 and FA.(3)The study revealed that after adjusting for age,sex,smoking,blood pressure,blood sugar,serum total cholesterol and triglyceride,hyperhomocysteinmia was associated with increased odds of cerebral infarction (OR=4 78,95% CI 1 7～13 46). Conclusions Hyperhomocysteinmia appears to have association with increased prevalent cerebral infarction. Hyperhomocysteinmia results from the relative deficiency of Vitamin B 12 and folic acid.