使用3-back范式比较不同COMTVal 158Met多态型的健康青年在连续心算中的视觉事件相关电位

针对不同COMT基因型健康青年被试者,进行连续心算任务3 h,使用数字3-back范式评定健康成人数字工作记忆能力变化情况.我们将115名健康青年分组抽取出20名不同基因型作为被试者,利用事件相关视觉诱发电位P3来观测被试者连续工作记忆任务中COMT基因多态型与脑皮层电生理的关系.结果表明,Val/Val基因型的被试者P3波幅显著高于Val/Met基因型(P＜0.01),与Met/Met基因型被试者的P3波幅无差异;在不同Block,不同基因型出现P3波幅增加的趋势.我们认为,数字工作记忆能力和中央区、顶区诱发的P3波幅相关,这反映了任务对被试者的难易程度.

Comparison of Visual Evoked Related Potentials in Healthy Young Adults of Different COMT Genotypes by Using a 3-back Paradigm During A Continuous Mental Arithmetic Task

To explore the change of numerical working memory ability in healthy young adults, continuous mental arithmetic task were performed for 3 hours and a numerical working memory paradigm was determined at 5 min intervals according to different COMT genotypes of young adults. Twenty subjects of different genotypes were chosen from 115 healthy young adults, P3 event-related potentials was utilized to observe the relationship between this COMT polymorphism and cortical physiology in a continuous working memory task. The results demonstrate that subjects bearing the Val/Val homozygote have significantly higher mean P3 amplitudes than Val/Met heterozygote (P<0.01), however, insignificant differences in comparison to Met/Met homozygote. Mean P3 amplitudes tended to sharply increase among different genotype subjects are observe in different Blocks. We suggest that numerical working memory ability was associated with P3 amplitude evoked from centro-parietal area of brain, which indicate the degree of influence of task on different subjects.