371例门诊输液不良反应／事件分析

目的分析引起门诊输液不良反应／事件的各种因素，探讨控制输液不良反应／事件的措施。方法对2003年6月～2008年6月我院门诊输液室发生的不良反应／事件病例进行统计分析。结果371例不良反应／事件涉及药物56种，抗生素引发者最常见（185例，49．9％），其次为中药注射剂（88例，23．7％）；发生不良反应，事件最短时间为5分钟，而10—30分钟有160例（43．1％）发生不适症状，是不良反应／事件发生的重要阶段；临床表现以皮肤及其附件损害为主。结论门诊输液应建立严格的不良反应监测系统，针对引起不良反应／事件的因素采取相应的预防措施，控制输液不良反应的发生率。

Analysis of 371 Adverse Drug Reaction/Event Cases Induced by Out-patient Injection

Objective To analyze the factors which cause the adverse drug reaction/event （ADR/ADE） induced by outpatient injection, and to explore how to control ADR/ADE. Methods ADR/ADE cases collected from the clinic injection room in our hospital have analyzed. Results There were 56 kinds of drugs related with 371 ADR/ADE, and antibiotics were in the first place（185 cases, 49.9%）, followed by the Traditional Chinese Medicine injection（88 cases, 23.7%）. The shortest time between infusion and ADR/ADE occurrence was five minutes, but 160 ADR/ADE cases （43.1%） occurred in 10~30 minutes after injection, so it is an important stage to inspect ADR/ADE. Lesions of the skin and the appendants is most. Conclusion To reduce the incidence of ADR/ADE induced by out-patient injection, our hospital should establish a strict ADR monitoring system, and take some preventive measures.