Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats |
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| Authors: | Marilyn E. Carroll Yang Gao Stephen Brimijoin Justin J. Anker |
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| Affiliation: | (1) Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA;(2) Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA |
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| Abstract: | ![]()
Rationale and objectives Previously, Albu-CocH, a cocaine hydrolase derived from human butyrylcholinesterase, blocked cocaine-induced reinstatement of drug seeking in rats. In the present study, rats were treated with Albu-CocH while self-administering cocaine under a progressive ratio (PR) schedule during 2-h sessions and under a fixed-ratio 1 (FR 1) schedule during 6-h sessions. |
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