|
|||||
|
|
| 酒石酸托特罗定的合成 | |
| 引用本文： | 孙钦美,马淑涛,张贵民. 酒石酸托特罗定的合成[J]. 齐鲁药事, 2010, 29(5): 301-303 |
| 作者姓名： | 孙钦美 马淑涛 张贵民 |
| 作者单位： | 1. 山东大学药学院,山东,济南,250012 2. 鲁南制药集团股份有限公司,山东,临沂,276006 |
| 摘 要： | 目的合成酒石酸托特罗定。方法以肉桂酸和对甲苯酚为起始原料,经环合、甲基化、还原、对甲苯磺酰化、胺化、脱甲基、拆分七步反应合成酒石酸托特罗定。结果与结论总收率为16.5%。该合成路线简洁,反应步骤少,适宜工业化生产。 |
| 关 键 词： | 酒石酸托特罗定 M-受体拮抗剂 药物合成 |
Synthetic of tolterodine tartrate |
|
| SUN Qin-mei,MA Shu-tao,ZHANG Gui-min. Synthetic of tolterodine tartrate[J]. qilu pharmaceutical affairs, 2010, 29(5): 301-303 | |
| Authors: | SUN Qin-mei MA Shu-tao ZHANG Gui-min |
| Affiliation: | (Shool of Pharmaceutical Sciences Shandong Univerisity,Ji＇nan 250012;1.Lunan Pharmaceutical Group Limited Company,Linyi 276006) |
| Abstract: | OBJECTIVE To synthesis tolterodine L-tratrate.METHODS Tolterodine tartrate was synthesized through the cyclization,methylation,reduction,sulfonylation,amidation,demethylation,separation from the starting material Cinnamic acid and P-cresp.RESULTS and CONCLUSION The total yield of the target compound was 18.7%.The synthetic procedure was convenient and suitable for industrial manufacture. |
| Keywords: | Tolterodine tartrate M-receptor antagonist synthesis |
| 本文献已被 维普 万方数据 等数据库收录！ | |