P糖蛋白和Ki-67抗原表达对肺癌T/NT的影响

目的:研究肺癌放射导向手术中肿瘤及正常组织P糖蛋白(P-gp)、Ki-67抗原表达与放射性核素摄取比(T/NT)的关系.方法:采用免疫组化方法和显微图像分析技术,测定32例接受放射导向手术的肺癌病人P-gp和Ki-67抗原表达,分析P-gp和Ki-67的标记指数(LI)与T/NT之间的相关性.结果:P-gp和Ki-67的LI和肺癌病人T/NT之间均有相关性(r=-0.61,P=0.0002; r=0.75,P=0.0001).结论:Ki-67的LI越高(肿瘤增殖越旺盛),T/NT值越高;P-gp阳性的肿瘤,T/NT值较低.

Effects of expression of P-glycoprotein and Ki-67 antigen on tumor/normal tissue in patients with lung cancer

Objective: To investigate the correlation ofth e expression of P-glycoprotein (P-gp) and Ki-67 antigen with tumor/normal tis sue (T/NT) ratio in patients with lung cancer underwent radioguided surgery.Methods: Patients(32) with lung cancer underwent radioguided surge ry were analysed retrospectively. Immunohistochemistry(S-P method) and microsco pe image analyzer were used to measure the expression of P-gp and Ki-67 antige n in lung cancer. The correlation between labeled index (LI) of P-gp or Ki-67and T/NT ratio were evaluated separately. Results: There weresignificant correlation between LI of P-gp or Ki-67 and T/NT ratio( r=-0.6 1, P=0.0002; r=0.75, P=0.0001 respectively). Conclusion: The higher the LI of Ki-67 (the higher in cell proliferation),thehigher the T/NT ratio. Patients with lung cancer and positive P-gp have low T/N T ratio.