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Taylor dispersion analysis compared to dynamic light scattering for the size analysis of therapeutic peptides and proteins and their aggregates
Authors:Hawe Andrea  Hulse Wendy L  Jiskoot Wim  Forbes Robert T
Affiliation:(1) Division of Drug Delivery Technology Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands;(2) PI Research Focus Group, School of Pharmacy, University of Bradford, Bradford, BD7 1DP, UK
Abstract:

Purpose  

To evaluate Taylor dispersion analysis (TDA) as a novel method for determination of hydrodynamic radius of therapeutic peptides and proteins in non-stressed and stressed formulations and to compare it with dynamic light scattering (DLS).
Keywords:
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