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| 晚期血吸虫病与肝脏自身免疫的关系 | |
| 引用本文： | 贺永文,宋光放,王心禾,金慰鄂,范红梅,陈华盛,王先棣. 晚期血吸虫病与肝脏自身免疫的关系[J]. 华中科技大学学报(医学版), 1986, 0(5) |
| 作者姓名： | 贺永文 宋光放 王心禾 金慰鄂 范红梅 陈华盛 王先棣 |
| 作者单位： | 同济医科大学附属协和医院传染病教研室(贺永文，王心禾，金慰鄂，范红梅)，济医科大学附属协和医院病理教研室(宋光放)，湖北江陵县血防站(陈华盛)，湖北汉川县血防站(王先棣) |
| 摘 要： | 本文结果显示25例晚期血吸虫病患者中15人抗-LSP阳性(60.0％),其抗-Lsp平均滴度显著高于正常人(P<0.001)。1年后随访证实部分晚血患者之抗-Lsp持续阳性。肝活检确诊为血吸虫病性肝纤维化者9例中,4例抗-Lsp阳性(44.4％);确诊为混合性肝硬化者4例中,3例阳性(75.0％)。进一步证实部分晚期血吸虫病患者体内的确存在针对肝脏的自身免疫反应。 |
| 关 键 词： | 血吸虫病 自身抗体 |
Further Research on Relationship Between Liver Disease of Late Stage of Schistosomiasis Japonica and Liver Autoimmunity |
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| He Yongwen,Song Guangfang,Wang Xinhe,Jin Weie,Fan Hongmei,Chen Huasheng,Wang Xiandi. Further Research on Relationship Between Liver Disease of Late Stage of Schistosomiasis Japonica and Liver Autoimmunity[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1986, 0(5) | |
| Authors: | He Yongwen Song Guangfang Wang Xinhe Jin Weie Fan Hongmei Chen Huasheng Wang Xiandi |
| Affiliation: | He Yongwen,Song Guangfang,Wang Xinhe,Jin Weie,Fan Hongmei,Chen Huasheng,Wang Xiandi Department of Infectious Diseases,Xiehe Hospital,Medical University,Wuhan Department of Pathological Anatomy,Tongji Medical University Prevention Station of Schistosomiasis,Jiangling County Prevention Station of Schistosomiasis,Hanchuan County |
| Abstract: | Present data show that antibody to a liver-specific membrane lipoprotein (anti-LSP) was detected in 15 of 25 patients with late stage schistosomiasis without the concomitent infection of viral hepatitis,and the average titer of anti-LSP in these patients was significantly higher than that in normal persons (P<0.001).Persistently elevated anti-LSP levels were found in some patients by follow-up study.Anti-LSP was positive in 4 of 9 late stage patients which were diagnosed by histologic examination as hepatic fibrosis(44.4%); and in 3 of 4 patients as hepatic fibrosis complicated by nodular cirrhosis (75%).This suggested that autoimmune reaction directed against liver was indeed present in some patients with late stage schistosomiasis. |
| Keywords: | schistosomiasis autoantibody |
| 本文献已被 CNKI 等数据库收录！ | |