| 药物因素对电致孔-离子导人体外经皮联合促渗技术的影响 |
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| 引用本文： | 李津明,刘畅,辛悦,李鑫,莫长涛. 药物因素对电致孔-离子导人体外经皮联合促渗技术的影响[J]. 黑龙江医药, 2011, 24(6): 890-893 |
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| 作者姓名： | 李津明 刘畅 辛悦 李鑫 莫长涛 |
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| 作者单位： | 哈尔滨商业大学,哈尔滨,150080 |
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| 基金项目： | 哈尔滨市科技创新人才研究专项资金项目(青年科技创新人才，黑龙江省教育厅科学技术研究项目 |
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| 摘 要： | 以氧化苦参碱、苦参碱、盐酸小檗碱、氨茶碱和秋水仙碱五种生物碱以及水杨酸、水杨酸钠和水杨酰胺为模型药物，采用电致孔一离子导入并用技术进行体外经皮给药途径的试验。结果得出药物分子量的大小、油／水分配系数、药物熔点、浓度、解离性质四种药物因素和不同部位皮肤的生理因素是影响电致孔一离子导入联合促渗技术的主要因素。
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| 关 键 词： | 电致孔 离子导入 联合促渗 |
Effect of the Drug Factors on Permeation Enhancement by Transdermal Delivery in Vitro Using Combination of Electroporation and Iontophoresis |
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| Affiliation: | Li Jinming1,et al 1.Harbin Commerce University(Harbin 150080) |
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| Abstract: | Five kinds of alkaloid were used including oxymatrine, matrine, berberine hydrochloride, aminophylline and colchicine as model drugs. Salicylic acid, sodium salicylate and salicylamide were also used as model drugs. Transdermal delivery of the drug using electroporation and iontophoresis was done in this research. The major factors influencing penetration en- hancement led by combiantion of electroporation and four drug factors, namely, drug molecular weignt, oil/water partition coef- ficient, melting point ,concentration and dissociative property. |
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| Keywords: | electreporation iontophoresis joint penetration enhancers |
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