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| 铁死亡在神经系统肿瘤中的作用及其机制研究进展 | |
| 引用本文： | 赵甦,李巧玉,孙而艺. 铁死亡在神经系统肿瘤中的作用及其机制研究进展[J]. 临床神经外科杂志, 2021, 18(1): 110-112,116 |
| 作者姓名： | 赵甦 李巧玉 孙而艺 |
| 作者单位： | 212002镇江,江苏大学附属人民医院神经外科;212002镇江,江苏大学附属人民医院神经外科;212002镇江,江苏大学附属人民医院神经外科 |
| 基金项目： | 江苏大学2018年度临床医学科技发展基金(JLY20180050)。 |
| 摘 要： | 铁死亡(ferroptosis)是近年来新提出的细胞死亡方式,其不同于传统的细胞死亡方式,区别于细胞凋亡、细胞坏死及自噬[1].其分子层面的特性有脂质活性氧(ROS)的铁依赖性积累、线粒体形态改变和膜通透性损伤[2I.在神经系统方面,研究发现其在帕金森病(PD)、阿尔兹海默病(AD)等神经变性疾病中起到了重要作用[3]... |
| 关 键 词： | 铁死亡 神经系统肿瘤 调节剂 |
Recent progress of ferroptosis in nervous system tumor |
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| ZHAO Su,LI Qiao-yu,SUN Er-yi. Recent progress of ferroptosis in nervous system tumor[J]. Journal of Clinical Neurosurgery, 2021, 18(1): 110-112,116 | |
| Authors: | ZHAO Su LI Qiao-yu SUN Er-yi |
| Affiliation: | (Department of Neurosurgery, People's Hospital Affiliated to Jiangsu University, Zhenjiang 212002, China) |
| Abstract: | Ferroptosis is a newly proposed cell death mode in recent years,which is different from the traditional cell death mode,apoptosis,cell necrosis and autophagy.Its molecular characteristics include iron-dependent accumulation of lipid reactive oxygen species(ROS),mitochondrial morphological changes and damage to membrane permeability.In the nervous system,studies have found that it plays an important role in neurodegenerative diseases such as Parkinson's disease(PD)and Alzheimer's disease(AD).With the further study on ferroptosis,it has been revealed that ferroptosis plays an important role in ischemic and hemorrhagic stroke and nervous system tumors.At present,the reviews on this aspect in China are relatively few.In this paper,the research progress in the mechanism of ferroptosis in nervous system tumors will be reviewed. |
| Keywords: | ferroptosis nervous system tumor regulator |
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