内镜下套扎联合药物治疗对肝硬化上消化道出血患者hs-CRP水平、肝功能的影响

目的 分析内镜下套扎联合药物治疗对肝硬化上消化道出血患者hs-CRP水平、肝功能的影响.方法 选取本院2017年6月至2020年8月收治且经临床确诊的100例肝硬化上消化道出血患者作为研究对象.根据不同的治疗方法分为联合组(n=52例,内镜下套扎联合奥美拉唑钠治疗)与单一组(n=48例,内镜下套扎治疗),比较两组围手术...

Effect of endoscopic variceal ligation combined with drug therapy on the level of hs-CRP and liver function in patients with liver cirrhosis combined with upper gastrointestinal hemorrhage

Objective To analyze the effect of endoscopic variceal ligation combined with drug therapy on the level of high sensitivity C-reactive protein(hs-CRP)and liver function in patients with liver cirrhosis combined with upper gastrointestinal hemorrhage.Methods 100 patients with liver cirrhosis combined with upper gastrointestinal hemorrhage who were admitted to our hospital from June 2017 to August 2020 and were clinically diagnosed were selected as the research objects.According to different treatment methods,they were divided into a combined group(n=52 cases,endoscopic variceal ligation combined with omeprazole sodium)and a single group(n=48 cases,endoscopic variceal ligation).The clinical efficacy,perioperative indicators,hs-CRP,cortisol and glucagon levels,and liver function indicators Alanine aminotransferase(ALT),aspartate amino Aspartate aminotransferase(AST),serum total bilirubin(TBIL),hemodynamic indicators and adverse reactions were compared between the two groups.Results The blood transfusion volume,hospitalization time,bleeding time and the improvement time of symptoms in the combined group were significantly lower than those in the single group,and the difference was statistically significant(P<0.05).After treatment,the serum factors of patients in the two groups:hs-CRP,cortisol and glucagon levels,liver function indicators:ALT,AST,TBIL and hemodynamic indicators:blood flow in portal vein,blood flow in splenic vein,inner diameter in portal vein and splenic vein were significantly lower than those before treatment,and the above indicators of the combined group were significantly lower than those of the single one,and the difference was statistically significant(P<0.05).No serious adverse reactions occurred in both groups.Conclusion Endoscopic variceal ligation combined with omeprazole sodium has a definite effect in the treatment of patients with liver cirrhosis combined with upper gastrointestinal hemorrhage,which can effectively improve the liver function and hemodynamics of varicose veins in patients with significant hemostatic effects and a certain degree of safety.