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| 低剂量辐射对HCT-8大肠癌细胞周期的影响 | |
| 引用本文： | 马琳,李啸峰,迟宝荣. 低剂量辐射对HCT-8大肠癌细胞周期的影响[J]. 肿瘤基础与临床, 2007, 20(4): 320-321 |
| 作者姓名： | 马琳 李啸峰 迟宝荣 |
| 作者单位： | 1. 中山大学附属第五医院,广东,珠海,519000 2. 吉林大学第一医院,吉林,长春,130021 |
| 摘 要： | 目的 采用低剂量辐射免疫兴奋效应的动物模型,探讨低剂量X射线照射对人大肠癌HCT-8细胞株细胞周期的影响.方法 采用流式细胞术(FCM)检测大肠癌细胞周期.结果 低剂量电离辐射照射后,大肠癌G0/G1期细胞百分数升高(P＜0.05),S期细胞百分数降低(P＜0.05),G2 M期细胞百分数升高(P＜0.05).结论 低剂量电离辐射可抑制大肠癌细胞的DNA合成及增殖. |
| 关 键 词： | 低剂量电离辐射 大肠癌 细胞周期 低剂量辐射 人大肠癌 细胞周期 影响 Large Intestine Carcinoma Cell Cycle Low Dose Radiation 增殖 合成 癌细胞 低剂量电离辐射 辐射照射 结果 检测 流式细胞术 方法 细胞株 射线照射 动物模型 |
| 文章编号： | 1673-5412（2007）04-0320-02 |
| 收稿时间： | 2006-11-01 |
| 修稿时间： | 2006-11-01 |
The Effect of Low Dose Radiation on Cell Cycle of Carcinoma of Large Intestine |
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| Ma Lin,Li Xiaofeng,Chi Baorong. The Effect of Low Dose Radiation on Cell Cycle of Carcinoma of Large Intestine[J]. journal of basic and clinical oncology, 2007, 20(4): 320-321 | |
| Authors: | Ma Lin Li Xiaofeng Chi Baorong |
| Affiliation: | 1. The Fifth Affiliated Hospital of Zhongshan University, Zhuhai 519000, China ; 2. The First Clinical Hospital of Jilin University, Changchun 130021, China |
| Abstract: | Objective In the present study we observed the effect of low dose radiation(LDR) on cell cycle of carcinoma of large intestine in human being.Methods The distribution in the phase of the cell cycle was analyzed by flow cytometry after staining of carcinoma cell of large intestine with propidium iodine(PI) with 0.075 Gy X-rays.Results It showed that the percentage of G0/G1 phase and G2 M phase of carcinoma cell of large intestine increased after irradiation(P<0.05),and mean while the percentage of S-phase of carcinoma cell of large intestine decreased after irradiation(P<0.05).Conclusions These results indicated that LDR could inhibit DNA synthesis of carcinoma cell of large intestine in human being. |
| Keywords: | low dose radiation carcinoma of large intestine cell cycle |
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