骨形成蛋白2在神经干细胞诱导分化中的作用

神经干细胞的多向分化潜能 ,使其成为替代治疗的内源性和外源性潜在细胞源 ,为治疗神经系统退行性疾病和中枢神经系统损伤带来了希望。神经干细胞的定向诱导分化 ,是当前神经干细胞研究领域的难点和热点。生长因子TGF beta超家族成员BMP2在骨发育形成中的重要作用已为许多研究所证实。近年来国内外对BMP2在神经系统发育中的作用进行了广泛研究 ,证实BMP2在诱导神经干细胞分化中发挥重要的作用 ,表现为一种多效性神经诱导因子。本文对近年来国际上关于BMP2诱导神经干细胞分化的研究做一综述

Functions of BMP2 on the differentiation of neural stem cells

The neural stem cells have become a promising cell source for transplant therapeusis because of their pluripotency in vivo and in vitro. It brings hope for therapy of the central injuries and neural degenerative diseases. The key problem is the differentiation of neural stem cells, which is the hot spot and tough problem of this field. Recently there are many research reports on the functions of BMP2 (bone morphogenetic protein 2, an important cytokine of TGF-beta super family) on the neural development. It has been confirmed that BMP2 has complex regulatory roles in the differentiation of neural stem cells. Here we review the research of the functions of BMP2 on the differentiation of neural stem cell recently.