粘液型铜绿假单胞菌耐药特性的实验研究

目的探讨粘液型铜绿假单胞菌的耐药性，为临床治疗选药提供依据。方法应用微量稀释法分别测试粘液型与非粘液型铜绿假单胞菌对常见12种抗生素的敏感性，并进行统计分析。结果粘液型铜绿假单胞菌对阿米卡星、妥布霉素和亚胺培南的敏感率均为100％，对头孢他定、复方派拉西林、复方替卡西林、派拉西林和奈替米星的敏感率均分别为93％，对替卡西林和环丙沙星的敏感率分别为86％，和79％，对复方新诺明的敏感率为47％。结论粘液型铜绿假单胞菌的体外耐药性较弱，且明显弱于非粘液型铜绿假单胞菌的耐药性（P＜0．005），但在临床用药时必须考虑粘液型铜绿假单胞菌在体内存在有生物膜的影响因素。

Experimental study on drug-resistant characteristics of mucoid pseudomonads aeruginosa

Objecitive To approach into the drug-resistant characteristics of mucoid pseudomonads aeruginosa for choosing the eligible antibiotic in clinic. Methods The microdilution method was applied to detect the sensitivities of common 12 kinds of antibiotics against mucoid and non-mucoid pseudomonads aeruginosa and analysed statistically. Results The sensitive rates of mucoid pseudomonads aeruginosa to amikacin, tobramycin and imipenem were 100%, next to the latter were 93% with ceftazidime, piperacillin-tazobactam, ticarcillin-clavulanic acid, piperacillin and netilmicin, and there were 86% in ticarcillin, 79% in ciprofloxacin, and 47% in trimethoprim-sulfamethoxazole, respectively. Conclusions Drug resistance of mucoid pseudomonads is weak in vitro, and also is obviously weaker than that of non-mucoid pseudomonads aeruginosa(P<0.005). It should consider the influencing factor being biomembrance of mucoid pseudomonads aeruginosa while using medcine in vivo.