单纯性肥胖患者血清瘦素与胰岛素、性激素的相关分析

[目的]观察单纯性肥胖患者血清瘦素水平与胰岛素、性激素浓度的父系。[方法]川放射免疫法测定64例肥胖者和65例非肥胖者的血清瘦素水平，并分析血清瘦素水平与年龄，体重指数（BMI）、腰臀比值（WHR）、胰岛素（INS）、睾酮（T、）雌二醇（E2）的相关性。[结果]1．无论肥胖组还是非肥胖组，女性血清瘦素水平显著高于男性（P〈0．01）；同性别比较，肥胖组显著高于非肥胖组（P〈0．01）。2．相关性分析，无论是男性还是女性，血清瘦素与BMI、WHR旱显著正相关，而与年龄无关。3．血清瘦素水平与胰岛素浓度呈正相关，与血糖浓度无关。4．血清瘦素水平与T，男性呈负相关（r=一0．310，P〈0．01），而女性呈正相关（r=0．360，P〈0．01）；与E2在男性无相关性，女性呈正相关（r=0．323，P〈0．01）。[结论]肥胖者窄腹血清瘦素水平升高，血清高瘦素与高胰岛索血症的相关性提示瘦素可能在2型糖尿病的发病中起一定作用。BMI足影响血清瘦素水平的主要原因之一，而性别间的差异则与性激素有关。

Correlation of serum leptin with insulin and sex hormones in simple obese patients

[ objectiveJ To investigate the relatlonsh~p between serum leptm and msuhn as well as sex hormones concentration m rampie obese patients. [ Methods] Serum leptin levels in 64 cases of obesity and 65 cases of non - obesity were determined with IRMA. Mean while, the relationship between serum leptin and age, BMI, WHR, plasma glucose, insulin （INS）, testosterone （T） as well as Estradiol （E2） was analyzed. [ Results] 1 ） Female serum leptin level was significantly higher than that of male in both obesity and non -obesity groups （P 〈0.01 ） while the serum leptin level was significantly higher in obesity group than that in non -obesity group in the same gender. 2 ） Correlative analysis showed that serum leptin was positively correlated with BMI and WHR but not with age in both male and female patients. 3 ） The serum leptin level was positively correlated with insulin concentration but not with plasma glucose. 4） Serum leptin level was negatively correlated with T in male patients （r = -0. 310, P 〈 0.05 ） but positively in female ones （r = 0. 360 ,P 〈 0.01 ） and E2 had no correlation with male gender but positively with female gender（ r =0. 323, P 〈0. O1 ）. [ Conclusion] Fasting serum leptin level is higher in obesity subjects than in non - obese ones. The correlation between hyperleptimia and hyperinsulinemia suggests a possible role of leptin in pathogenesis of type 2 diabetes. BMI is one of the main factors affecting serum leptin while the difference of sex hormones is correlated with sex.