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| VEGF、PCNA在肺癌组织中的表达及其意义 | |
| 引用本文： | 郭广松,刘建军,徐世杰,郭勤. VEGF、PCNA在肺癌组织中的表达及其意义[J]. 武汉大学学报(医学版), 2001, 22(1): 12-13 |
| 作者姓名： | 郭广松 刘建军 徐世杰 郭勤 |
| 作者单位： | 1. 武汉大学中南医院病理科 2. 武汉大学基础医学院病毒学研究所, 3. 武汉大学人民医院外科, |
| 基金项目： | 国家自然科学基金!资助课题，批准号 :39870 6 5 9 |
| 摘 要： | 目的 :探讨肺癌组织中血管内皮生长因子 (VEGF)、增殖细胞核抗原 (PCNA)的表达及其与肺癌临床分期、病理分型的关系。方法 :采用免疫组织化学技术SP法 ,检测 88例人肺癌组织和 30例人癌旁肺组织中VEGF和PCNA的表达。结果 :VEGF、PCNA在肺癌组织中的表达率分别为 71.6 %、70 .5 % ,与正常肺组织中的表达率相比 ,P值均小于 0 .0 5。VEGF、PCNA均与肺癌的临床分期呈正相关 ,而与病理分型无关。结论 :检测肺癌组织中的VEGF、PCNA的表达有助于肺癌的临床分期 ,并为肺癌的发生发展提供理论基础。 |
| 关 键 词： | 肺肿瘤 内皮生长因子 增殖细胞核抗原 |
Expressions of VEGF and PCNA in Lung Cancer Tissues and Their Significance |
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| Guo Guang song,Liu Jian jun,Xu Shi jie,et al. Expressions of VEGF and PCNA in Lung Cancer Tissues and Their Significance[J]. Medical Journal of Wuhan University, 2001, 22(1): 12-13 | |
| Authors: | Guo Guang song Liu Jian jun Xu Shi jie et al |
| Affiliation: | Guo Guang song,Liu Jian jun,Xu Shi jie,et al Department of Pathology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China |
| Abstract: | Objective:To investigate the expressions of vascular endothelial growth factor (VEGF) and proliferation cell nuclear antigen (PCNA) and their significance.Methods:Surgical samples of 88 patients with primary lung cancer and 30 normal tissues near the cancer were measured using immunohistochemistry.Results:Positive expression rates of VEGF and PCNA in lung cancer tissues were 71.6% and 70.5% respectively(Both P <0.05),compared with normal control.VEGF and PCNA were positively correlated with clinical stages of lung cancer,and both of them had no connection with pathological types.Conclusion:Determination of PCNA and VEGF in lung cancer tissues contributes to clinical staging and provides theoretical basis about the development of lung cancer. |
| Keywords: | lung neoplasms endothelial growth factors PCNA |
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