急性髓系白血病合并慢性淋巴细胞白血病一例报道及文献复习

 目的 探讨急性髓系白血病（AML）合并慢性淋巴细胞白血病（CLL）的临床特点、病因、诊断、治疗及预后。方法 临床诊断1例AML合并CLL，并就相关文献进行复习。结果 患者经MA方案（米托蒽醌10 mg／d第1 ~ 3天，阿糖胞苷150 mg／d第1，3，5，7天，200 mg第2，4，6天）化疗后取得完全缓解，但CD19阳性的淋巴细胞（表达CD20，CD23，SIgM，部分表达CD5，CD22，CD25）仍然存在，于9个月后AML复发未能再次缓解而死亡。结论 AML合并CLL为一种具有特殊生物学特征的罕见疾病，免疫分型和细胞遗传学技术在疾病的诊断和认识中发挥重要作用，治疗应以AML为主。

Acute myelogenous leukemia concurrent with chronic lymphocytic leukemia one case report and review literature

Objective To investigate the clinical characteristics, pathogenesis, diagnosis, therapeutics and prognosis of acute myelogenous leukemia(AML) concurrent with chronic lymphocytic leukemia (CLL). Methods One case of AML concurrent with CLL was diagnosed and literatures were reviewed. Results The patient achieved complete remission with MA regimen. But the lymphocytes that expressing CD19,CD20, CD23,SIgM positive ( part of the cell CD5, CD22, CD25 positive) were still existing. The patient died of AML relapse 9 months later. Conclusion The concomitant AML and CLL is a rare disease with particular biological characteristic. Flow cytometry and cytogenesis are helpful to diagnose and recognize the disease. Therapeutics always uses the regimen of the AML. <