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Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design |
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| Authors: | Furet Pascal Imbach Patricia Noorani Maria Koeppler Juergen Laumen Kurt Lang Marc Guagnano Vito Fuerst Peter Roesel Johannes Zimmermann Johann García-Echeverría Carlos |
| Affiliation: | Novartis Pharma AG, Novartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland. |
| Abstract: | Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays. |
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