首页 | 本学科首页   官方微博 | 高级检索  
     


Postmortem Diagnosis of Acute Megakaryocytic Leukemia Usefulness of lmmunohistochemistry and Tissue Hemogram
Authors:Akihiro Umezawa  Taketo Yamada  Yuuto Ogawa  Shigeru Kuramochi  Yonosuke Watanabe
Affiliation:Department of Pathology, Keio University School of Medicine, Tokyo.
Abstract:
An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)- positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa-positive blasts and megakaryoblasts were deposited massively in lymph nodes. lmmunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultra-structural platelet peroxidase in autopsy materials is difficult.
Keywords:Acute megakaryocytic leukemia    Immunohistochemistry    Glycoprotein IIb/IIIa    Tissue hemogram
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号