| p53和c-erbB-2型在卵巢上皮性癌中的表达及其临床意义 |
| |
| 引用本文： | 范金兰,于会敏,冯秋红,宋俊芬. p53和c-erbB-2型在卵巢上皮性癌中的表达及其临床意义[J]. 河北医科大学学报, 2000, 21(2): 87-89 |
| |
| 作者姓名： | 范金兰 于会敏 冯秋红 宋俊芬 |
| |
| 作者单位： | 河北医科大学第四医院妇产科,石家庄050011;河北医科大学第四医院妇产科,石家庄050011;河北医科大学第四医院妇产科,石家庄050011;河北医科大学第四医院妇产科,石家庄050011 |
| |
| 摘 要： | 探讨卵巢上皮性癌ｐ５３和ｃ－ｅｒｂＢ－２表达的临床意义。方法用免疫组织化学法检测ｐ５３和ｃ－ｅｒｂＢ－２,结合临床病理及肿瘤的生物学行为进行分析。结果ｐ５３在高分化果中的表达频率显著低于中、低分化癌、Ｐ５３表达阳性组的卵巢癌对化疗不敏感、其预后亦明显劣于阴性组卵巢癌。
|
| 关 键 词： | 卵巢肿瘤/代谢 p53蛋白质/代谢 癌基因/免疫学 组织学技术 卵巢肿瘤/药物疗法 药物耐受性 |
SIGNIFICANCE OF EXPRESSION OF p53 AND c-erbB-2 IN OVARIAN EPITHELIAL CARCINOMA |
| |
| Fan Jinlan,Yu Huimin,Feng Qiuhong,Song Junfen. SIGNIFICANCE OF EXPRESSION OF p53 AND c-erbB-2 IN OVARIAN EPITHELIAL CARCINOMA[J]. Journal of Hebei Medical University, 2000, 21(2): 87-89 |
| |
| Authors: | Fan Jinlan Yu Huimin Feng Qiuhong Song Junfen |
| |
| Affiliation: | Shijiazhuang 050011 |
| |
| Abstract: | ObjectiveTo explore the clinical significance of p 53 and c erbB 2 expression in ovarian epithelial carcinoma.MethodsThe expression of p 53 and c erbB 2 were examined by immunohistochemical method,and the relationship between the expression of two factors and clinicopathologic features resistant to chemotherapy and prognosis were analyzed.ResultsThe expression p 53 had significant lower frequency in well differentiated ovarian tumor than that in medium and poor differentiated one.p 53 positive tumors related with drug resistance and poor prognosis significantly.The expression of c erbB 2 was not associated with clinical stage,histologic type,grade, residual tumor,chemotherapy and prognosis.Conclusionp 53 expression in ovarian cancer is related to drug resistance,and it is a useful prognostic index. |
| |
| Keywords: | ovarian neoplasms/metab protein p 53 /metab oncogene/immunol histological technics ovarian neoplasms/drug ther drug tolerance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
