糖尿病肾病早期诊断的相关性研究

微量蛋白尿(MA)是糖尿病肾病(DN)的早期表现,判定MA即可诊断为初始DN。MA的检测方法有随机采样检测、24 h尿样检测和定时(如4 h或隔夜)测定尿白蛋白/肌酐比率法,任意一种检测方法至少有2次检测呈阳性,持续3～6个月,并排除其他原因,即可确诊为MA。DN一经早期诊断,即刻采取严密控制血糖于理想水平、抗高血压疗法和转换酶抑制剂或血管紧张素受体阻滞剂保护性干预、控制血压<130/80 mm Hg的理想水平等干预措施,藉以控制和延缓DN进展速度。

Correlation Studies about Early Diagnosis of Diabetic Nephropathy

Microalbuminuria is an early stage manifestation of diabetic nephropathy(DN),which can be a judgment basis of initial diabetic nephropathy.The measurements include the urine sample random spot collection;24-h collection urine sample,and timed(e.g.,4 h or overnight) collection of urine sample for determining albumin-to-creatinine ratio.At least 2 times positive of any test lasting for 3-6 months with elimination of other causes can be diagnosed as microalbuminuria.Once DN is early diagnosed,interventions such as close control of blood sugar on the ideal level,ACEI and ARBs protection therapy should be given to control the blood pressure at < 130 /80 mm Hg ideal level,so as to control and delay DN progress speed.