普伐他汀对慢性心力衰竭患者心率变异性的影响

目的探讨普伐他汀对慢性心力衰竭（CHF）患者心率变异性（HRV）的影响。方法对符合入选标准的78例CHF患者分为普伐他汀组（39例）和对照组（39例）。对照组给予常规治疗，治疗组在原治疗基础上加用普伐他汀20mg／d。两组治疗前、治疗后4周检测HRV的变化。结果普伐他汀组和对照组治疗后HRV各项指标明显高于治疗前（P〈0．05）；普伐他汀组治疗后HRV各项指标均明显高于对照组（P〈0．05）。结论普伐他汀可通过改善CHF患者心脏自主神经功能而提高HRV，从而改善CHF患者的预后。

Effect of Pravastatin on Heart Rate Variability in Chronic Heart Failure

Objective To investigate the effect of pravastatin on heart rate variability （HRV） in chronic heart failure （CHF）. Methods Seventy-eight cases of CHF were randomly divided into pravastatin group （n=39） and control group （n=39）. Both groups received the routine treatment and pravastatin 20mg/d was added to the pravastatin group. The HRV changes of the two groups were detected before treatment and after fourweek treatment. Results HRV was significantly increased in the two groups after treatment compared with that before treatment （P〈.05）. After 4-week treatment,the parameters of HRV in the pravastatin group were significantly higher than those in the control group（P〈0.05）. Conclusion Pravastatin can improve the cardiac autonomic nerve function of patients with CHF, and then increase the parameters of HRV and improve the prognosis of CHF.