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| Prenatal diagnosis of Werdnig Hoffmann disease in China | |
| 作者单位： | Department of Neurology, Children’s Hospital, Zhejiang University, Hangzhou 310027, China;Gene Research Center, Tottori University, Yonago 6838503, Japan |
| 摘 要： | Objective To establish a means for prenatal prediction of spinal muscular atrophy (SMA) through survival motor neuron (SMN) gene deletion analysis and genetic counseling in families with a child affected with SMA. Methods Genetic analysis for prenatal prediction of Werdnig-Hoffmann disease was performed in a at risk Chinese family by polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) in SMN gene exons 7 and 8. Results The pregnancy was positive for the homozygous deletion of the SMN gene, thus the fetus was diagnosed as being affected and the pregnancy was terminated. Conclusion This approach is fast and reliable for DNA-based prenatal diagnosis of Werdnig-Hoffmann disease. |
| 关 键 词： | spinal muscular atrophies of childhood prenatal diagnosis SSCP |
Prenatal diagnosis of Werdnig Hoffmann disease in China |
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| Authors: | FENG Jianhua Toshiyuki Yamamoto |
| Abstract: | Objective To establish a means for prenatal prediction of spinal muscular atrophy (SMA) through survival motor neuron (SMN) gene deletion analysis and genetic counseling in families with a child affected with SMA. Methods Genetic analysis for prenatal prediction of Werdnig-Hoffmann disease was performed in a at risk Chinese family by polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) in SMN gene exons 7 and 8.Results The pregnancy was positive for the homozygous deletion of the SMN gene, thus the fetus was diagnosed as being affected and the pregnancy was terminated.Conclusion This approach is fast and reliable for DNA-based prenatal diagnosis of Werdnig-Hoffmann disease. |
| Keywords: | spinal muscular atrophies of childhood prenatal diagnosis SSCP |
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