氟芬那酸丁酯软膏治疗儿童特应性皮炎的临床疗效观察

目的评价氟芬那酸丁酯软膏联合肤舒止痒膏外用治疗儿童特应性皮炎的临床疗效和安全性。方法将皮肤科门诊自2010年7月q012年6月的儿童特应性皮炎患者122例，皮疹无明显糜烂、渗出和结痂。符合Williams所制定的AD诊断标准。随机分为治疗组和对照组，每组61例。治疗组患者联合应用氟芬那酸丁酯软膏和肤舒止痒膏，对照组外采用糠酸莫米松软膏涂抹皮损处，临床观察疗程为2周。所有病例在治疗结束后均进行SCORAD评分和有效率的评价。结果男性患者74例，女性患者48例，年龄2～7周岁，病程1月～7年；治疗前，治疗组及对照组皮疹积分无显著性差异，分别为12．44±2．31和11．98±3．12；治疗后，治疗组皮疹积分（5．13±3．47）显著低于对照组（7．72±4．08），两者相比差异有统计学意义（P〈0．01）。治疗组患者症状的SCO—RAD评分总积分为8．10±3．35，显著低于对照组患者的11．20±3．97，（P〈0．01）；治疗前，治疗组及对照组瘙痒积分无显著性差异，分别为6．59±1．74和6．26±1．86；治疗后，治疗组瘙痒积分（2．97±1．01）略低于对照组（3．48±1．27），但两者相比差异无统计学意义（P〉0．05）；治疗组患者的有效率为49．18％，明显高于对照组患者的24．59％，（P〈0．01）。2组患者均未出现各种药物相关的临床不良反应。结论运用氟芬那酸丁酯软膏联合肤舒止痒膏治疗儿童特应性皮炎，安全性较高，治疗效果较为明确，适合在临床上广泛运用。

Effect of butyl flufenamate ointment combined with Fushuzhiyanggao in treatment of atopic dermatitis in children

Objective To evaluate the clinical efficacy and safety of Butyl flufenamate ointment combined with Fushuzhiyanggao in the treatment of children with atopic dermatitis. Methods 122 children with atopic dermatitis from July 2010 to June 2012, which were accord to the standard of Williams AD diagnosis and all the cases with shin rash without obvious erosion, seepage and scabby. They were randomized into treatment （ n = 61 ） and control group （ n = 61 ）. Children in treatment group received a combined therapy of butyl flufenamate and Fushuzhiyanggao. Children in control group were topically applied with mometasone furoate ointment. Both groups were treated with oral antihistamines. SCORADs and ef- fective rates were observed after 2 weeks of treatment. Results The cases include 74 boys and 48 girls, with the age from 2 years old to 7 years old. Before the treatment, rash integration between the treatment group（ 12.44±2.31 ） and the control group （11.98± 3.12 ） was no significant difference; After treatment, the treatment group （5.13 ±3.47） was sig- nificantly lower than the control group （7.72 ± 4.08 ） （P 〈 0. 01 ） ; SCORAD was remarkably lower （P 〈 0. 01 ） in treat- ment group （8.10 ± 3.35 ） than in control group （11.2 ± 3.97 ） ; Before the treatment, pruritus integration between the treatment group（6.59 ± 1.74） and the control group（2.97 ± 1.01 ） was no significant difference. After treatment, the treatment group （2.97 ± 1.01 ） slightly lower than the control group （ 3.48± 1.27 ） but there was significantly （ P 〈 0.01 ） and a significant difference （P 〈0.01 ） was observed in effective rates between treatment （49.18%） and control group （49.18%）. No drug-related adverse events occurred for two groups. Condusion A therapy of butyl flufenamate com- bined with Fushuzhiyanggao is safe and effective in the treatment of children with atopic dermatitis, which is suitable for widely use in clinic.