| 血管内皮细胞生长因子在急性肺损伤中的作用 |
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| 引用本文： | 张曌,张诗海. 血管内皮细胞生长因子在急性肺损伤中的作用[J]. 国际麻醉学与复苏杂志, 2010, 31(6). DOI: 10.3760/cma.j.issn.1673-4378.2010.12.014 |
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| 作者姓名： | 张曌 张诗海 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院麻醉科,武汉,430022;华中科技大学同济医学院附属协和医院麻醉科,武汉,430022 |
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| 摘 要： | 急性肺损伤(acute lurg injury,ALI)和急性呼吸窘迫综合征(acute respiratory distressyndrome,ARDS)的特征性病理改变为肺毛细血管通透性增高所致的肺水肿,血管内皮细胞生长因子能抗血管内皮细胞凋亡并增加血管通透性,可能在ALI和ARDS的病理过程中起到重要作用.现对血管内皮细胞生长因子在ALI中的作用进行综述,旨在为ALI和ARDS的治疗提供新的思路.
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| 关 键 词： | 血管内皮细胞生长因子 急性肺损伤 急性呼吸窘迫综合征 |
Vascular endothelial growth factor in acute lung injury |
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| ZHANG Zhao,ZHANG Shi-hai. Vascular endothelial growth factor in acute lung injury[J]. international journal of anesthesiology and resuscitation, 2010, 31(6). DOI: 10.3760/cma.j.issn.1673-4378.2010.12.014 |
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| Authors: | ZHANG Zhao ZHANG Shi-hai |
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| Abstract: | Increased permeability and interstitial pulmonary edema are prominent features of acute lung injury (ALI)/acute respiratory distress syndrome(ARDS).Vascular endothelial cell growth factor(VEGF) has been identified by its properties to increase permeability and act as a cellular growth factor, thus it is a potential key role in the pathogenesis of ALI/ARDS. Understanding the role of VEGF in this disease process is crucial for developing new therapeutic strategies for ALI/ARDS. |
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| Keywords: | Vascular endothelial growth factor Acute lung injury Acute respiratory distresssyndrome |
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