| 胰岛素对局灶性脑缺血再灌注大鼠c—fos和bcl—2基因表达的影响 |
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| 引用本文： | 曹勇军,程彦斌.胰岛素对局灶性脑缺血再灌注大鼠c—fos和bcl—2基因表达的影响[J].中风与神经疾病杂志,2001,18(5):294-296. |
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| 作者姓名： | 曹勇军 程彦斌 |
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| 作者单位： | 兰州医学院神经解剖研究室, |
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| 摘 要： | 目的探讨胰岛素对脑缺血再灌注损伤的中枢保护机制.方法参照ZeaLonga线栓法建立大鼠局灶性脑缺血再灌注模型,采用免疫组化法检测同一剂量胰岛素(2IU/kg)对缺血再灌注不同时限点脑组织FOS和BCL-2蛋白的表达.结果与假手术对照组和未用药组相比,胰岛素能显著上调缺血侧大脑皮层及基底节区FOS和BCL-2蛋白的表达(P<0.001).结论胰岛素能促进缺血再灌注脑组织FOS和BCL-2蛋白的表达,这可能是其中枢保护机制之一.
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| 关 键 词： | 胰岛素 脑缺血 再灌注损伤 c－fos bcl－2 FOS蛋白 BCL－2蛋白 |
| 文章编号： | 1003-2754(2001)05-0294-03 |
| 修稿时间： | 2001年1月9日 |
Effects of insulin on c-fos and bcl-2 genes expression in rats with focal cerebral ischemia followed by reperfusion |
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| CAO Yong-jun,CHENG Yan-bin..Effects of insulin on c-fos and bcl-2 genes expression in rats with focal cerebral ischemia followed by reperfusion[J].Journal of Apoplexy and Nervous Diseases,2001,18(5):294-296. |
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| Authors: | CAO Yong-jun CHENG Yan-bin |
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| Abstract: | Objective To investigate the mechanism of the central neuroprotection of insulin on cerebral ischemia-reperfusion injury. Methods The model of focal cerebral ischemia-reperfusion in rats was established with the suture-occluded method invented by Zea Longa,the expression of FOS and BCL-2 protein in rats pretreated with insulin(2IU/kg)during the different time of cerebral ischemia-reperfusion were observed by immunohistochemical method. Results Compared with the control groups,insulin can significantly increased the expression of FOS and BCL-2 protein both in the ischemic cerebral cortex and in basal ganglia (P<0.001). Conclusion To increase the expression of FOS and BCL-2 protein may be one of the mechanisms of the central neuroprotection of insulin. |
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| Keywords: | Insulin Cerebral ischemia Reperfusion injury c-fos bcl-2 FOS protein BCL-2 protein |
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