肺炎支原体肺炎患儿T淋巴细胞亚群变化的临床意义

目的:检测肺炎支原体肺炎(MPP)患儿机体细胞免疫功能的变化,为MPP免疫学治疗提供进一步依据。方法:选取2013年7¹2月于本院确诊为MPP的患儿60例,对照组为同期门诊体检健康儿童60例,分别检测两组儿童外周静脉血中T淋巴细胞亚群的表达水平。结果:MPP组患儿的CD3+、CD4+、CD8+、CD4+/CD8+表达水平(x珋±s,%)分别为69.12±8.07、37.76±8.22、27.96±9.28、1.53±0.56。与健康对照组儿童相比,MPP组患儿的CD3+、CD4+、CD4+/CD8+表达水平显著下降,而CD8+表达水平则显著升高(P<0.01)。结论:MPP患儿T淋巴细胞亚群表达失调,细胞免疫功能紊乱可能在MPP发病过程中起着重要作用。

Significance of T lymphocyte subsets variation in children with mycoplasma pneumoniae pneumonia

Objective：To detect the changes of T lymphocyte subsets in children with mycoplasma pneumoniae pneumonia （ MPP） for basis with immuno-logical therapy for MPP.Methods：Sixty children diagnosed as MPP in our hospital between July 2013 and December 2013 were included,and another 60 healthy children undergoing the physical examination at the out-patient in the corresponding period were recruited as controls.The peripheral blood was ob-tained from the two groups and measured for the levels of T lymphocyte subsets.Results：The levels of CD3^＋,CD4^＋,CD8^＋and CD4^＋/CD8^＋were 69.12 ＆#177;8.07,37.76 ±8.22,27.96 ±9.28 and 1.53 ±0.56,respectively,for the in MPP group,whose CD3^＋,CD4^ ＋and CD4 ＋/CD8^＋levels were signifi-cantly decreased,yet CD8 ＋level was markedly elevated as compared with the controls（P〈0.01）.Conclusion：Imbalanced T lymphocyte subsets were found in children with MPP,which suggests that cellular immune dysfunction may play an important role in the pathogenesis of mycoplasma pneumoniae pneumonia.