| 蛋白质组学与胃肠相关心因性疾病 |
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| 引用本文： | 张茹,钱家鸣,吕红. 蛋白质组学与胃肠相关心因性疾病[J]. 胃肠病学, 2009, 14(5): 310-312. DOI: 10.3969/j.issn.1008-7125.2009.05.015 |
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| 作者姓名： | 张茹 钱家鸣 吕红 |
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| 作者单位： | 中国医学科学院,北京协和医学院,北京协和医院消化科,100730 |
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| 摘 要： | 蛋白质组学以细胞、组织或机体内全部蛋白质为研究对象,研究其结构、功能和相互作用,具有高敏感性和特异性。蛋白质组学可发现精神疾病的特异性标记物,提高对精神疾病病理和发病机制的认识。采用蛋白质组学检测精神疾病的特异性蛋白质图谱,继而建立实验诊断模型,可为精神疾病的病因、诊断、分型、潜在药物靶点等的研究提供科学依据。本文就蛋白质组学与胃肠相关心因性疾病的关系作一综述。
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| 关 键 词： | 蛋白质组学 精神障碍 肠易激综合征 |
Proteomics and Gastrointestinal-related Mental Disorders |
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| ZHANG Ru,QIAN Jiaming,LV Hong. Proteomics and Gastrointestinal-related Mental Disorders[J]. Chinese Journal of Gastroenterology, 2009, 14(5): 310-312. DOI: 10.3969/j.issn.1008-7125.2009.05.015 |
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| Authors: | ZHANG Ru QIAN Jiaming LV Hong |
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| Affiliation: | .( Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing (100730) |
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| Abstract: | Proteomics studies the structure, function of the proteome and their interaction in the cell, tissue and body. Proteomies has the merits of high sensitivity and specificity. Proteomics can be used to find specific markers of mental disorders, which can improve the recognition of pathology and pathogenesis of mental disorders. We can use proteomics to find specific protein fingerprint, and construct diagnostic models of mental disorders, therefore provide scientific foundation for the study of etiology, diagnosis, typing and potential drug targets. This article reviewed the relationship between proteomics and gastrointestinal-related mental disorders. |
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| Keywords: | Proteomics Mental Disorders, Irritable Bowel Syndrome |
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