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Effect of lithium carbonate on memory processes of bipolar affectively ill patients |
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| Authors: | Victor I. Reus Steven D. Targum Herbert Weingartner Robert M. Post |
| Affiliation: | (1) Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, 20014 Bethesda, Maryland, U.S.A.;(2) Section on Psychogenetics, Biological Psychiatry Branch, National Institute of Mental Health, 20014 Bethesda, Maryland, U.S.A.;(3) Laboratory of Psychology, National Institute of Mental Health, 20014 Bethesda, Maryland, U.S.A.;(4) Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, 20014 Bethesda, Maryland, U.S.A.;(5) Present address: Langley Porter Neuropsychiatric Institute, University of California, School of Medicine, 94143 San Fransisco, CA, U.S.A. |
| Abstract: | The effect of long-term lithium carbonate treatment on parameters of immediate, short-, and long-term memory was examined in a group of bipolar affectively ill patients. The lithium treatment group recalled significantly fewer words across trials on a verbal learning task than a group of bipolar affectively ill patients receiving no medication. The ability to consistently recall material for which prior learning had been demonstrated was also decreased and accounted for most of the variance in total number of words recalled. Possible mechanisms of effect are discussed. |
| Keywords: | Lithium carbonate Memory Affecive illness Depression |
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