| 高脂血清对易感和不易感动脉粥样硬化动物的动脉平滑肌细胞生长的影响 |
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| 引用本文： | 夏人仪,赵三妹,蔡春波,刘佩毛,冉碧芳,陶保卫,王宗立,佘铭鹏.高脂血清对易感和不易感动脉粥样硬化动物的动脉平滑肌细胞生长的影响[J].基础医学与临床,1989(1). |
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| 作者姓名： | 夏人仪 赵三妹 蔡春波 刘佩毛 冉碧芳 陶保卫 王宗立 佘铭鹏 |
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| 作者单位： | 中国医学科学院基础医学研究所病理研究室
(夏人仪，赵三妹，蔡春波，刘佩毛，冉碧芳，陶保卫，王宗立)，中国医学科学院基础医学研究所病理研究室(佘铭鹏) |
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| 摘 要： | 体外培养家兔和树鼩为主动咏平滑肌细胞,分别观察各自的高脂血清对平滑肌细胞生长的影构,以~3H-胸腺嘧啶核苷(~3H—TdR)掺入细胞DNA,用液体闪烁计数器计数。结果表明:兔高脂血清对兔平滑肌细胞生长有显著的增殖作用,而树鼩高脂血清对树鼩平滑肌细胞的生长未见显著的促进增生作用。
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| 关 键 词： | 高脂血清 低密度脂蛋白 动脉粥样硬化 动脉平滑肌细胞 |
Effect of Hyperlipidemic Serum on Proliferation of Aortic Smooth Muscle Cells from Animals Susceptible or non-susceptible to Atherosclerosis |
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| Xia Renyi Zhao Sanmei Cai Chunbo Liu Peimao Ran Bifang Tao Baowei Wang Zongli She Mingpeng.Effect of Hyperlipidemic Serum on Proliferation of Aortic Smooth Muscle Cells from Animals Susceptible or non-susceptible to Atherosclerosis[J].Basic Medical Sciences and Clinics,1989(1). |
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| Authors: | Xia Renyi Zhao Sanmei Cai Chunbo Liu Peimao Ran Bifang Tao Baowei Wang Zongli She Mingpeng |
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| Abstract: | It is known that rabbits are susceptible and Tree Shrews are resistant to the development of atherosclerotic lesions. Cultivated smooth muscle cells originated from the thoracic aortae of both animals were used respectively in studying the effecte of hyperlipidemic sera on the proliferation of the above cells. A concentration of 5 % hyperlipidemic serum in media was selec ted for by feeding with a high cholesterol diet and the effect on proliferation were measured with liquid Scintillation counter by incorporating the cultivated cells with 3H-TdR.The results showed that addition of rabbits hyperlipidemic serum gave a more significant increase of proliferation rate of smooth muscle cells than that induced by normal serum, however, the preliminary data showed that hyperlipidemic serum of Tree Shrews gave no significant effect on the proliferation of smooth muscle cells. |
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| Keywords: | hyperlipidemic serum low density lipoprotein atherosclerosis arterial smooth muscle cell |
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