胰岛素受体底物-1与骨代谢 |
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引用本文: | 何玉玲[综述] 周后德[审校]. 胰岛素受体底物-1与骨代谢[J]. 中国医学文摘:老年医学, 2012, 0(8): 792-794 |
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作者姓名: | 何玉玲[综述] 周后德[审校] |
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作者单位: | 广西医科大学第一附属医院代谢糖尿病中心,南宁530021 |
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摘 要: | 胰岛素受体底物(insulinreceptorsubstrate,IRS)是胰岛素信号传导通路中受体后水平的重要信号蛋白。IRS-1对骨骼生长、骨转换以及骨折愈合等均具有重要作用,为代谢性骨病和骨质疏松的防治提供了新思路。
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关 键 词: | 胰岛素受体底物-1 骨代谢 |
Insulin receptor substrate-1 and bone metabolism |
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Affiliation: | HE Yu-ling ,ZHOU Hou-de. The Metabolism and Diabetes Mel- litus Research Center, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China |
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Abstract: | Insulin receptor substrate (IRS) is an important signaling proteins in insulin signal transduction pathways. IRS-1 plays an important role in skeletal growth, bone turnover and bone fracture healing. It may be a new point for the prevention and treatment of metabolic bone disease and osteoporosis. |
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Keywords: | Insulin receptor substrate-1 Bone metabolism |
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