高敏C反应蛋白与冠心病病变严重程度的关系

目的:探讨高敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)与冠心病(coronary heart disease,CHD)病变严重程度的关系。方法:测定经冠状动脉造影(coronary angiography,CAG)确诊的85例冠心病患者血浆中hs-CRP浓度。85例患者按照血管病变支数分为单支血管病变组(n=31)、双支血管病变组(n=26)及三支血管病变组(n=28),同时以冠状动脉造影CAG排除冠心病的32例正常人作为对照组,比较各组间血浆hs-CRP浓度。结果:冠心病患者各组hs-CRP浓度均较正常对照组增高(P<0.05)。在冠心病各亚组中hs-CRP浓度差异无统计学意义(P>0.05)。结论:冠心病患者血浆hs-CRP浓度高于正常人,但hs-CRP浓度与冠状动脉病变支数无关系。

Correlation between serum high sensitive C-reactive protein and severity of coronary artery disease

Objective:To study the correlation of serum high sensitive C-reactive protein(hs-CRP)and the severity of coronary heart disease(CHD).Methods:Eighty-five cases diagnosed with CHD by selected coronary angiography(SCA)were divided into three groups including single vessel lesion(31 cases),double vessel lesions(26 cases)and tri-vessel lesions(28 cases),thirty-two cases with nomal SCA were used as control.The serum content of hs-CRP was measured by latex agglutination turbidimetric method.Results:Hs-CRP was higher in the cases with CHD than that in control groups(P<0.05).But there is no significant difference(P>0.05)in the levles of hs-CRP among the three groups with CHD.Conclusion:The serum level of hs-CRP was higher in the groups of CHD than that in control grooups,but there is no correlation between the levels of hs-CRP and vessel lesion severity in the groups of CHD.