人肺癌组织内微循环研究及其模型在裸鼠体内的建立

Patterns of Microcirculation on Human Lung Cancer Tissue in Nude Mice

The condition of the blood capillary bed and type of microcirculation in human lung cancer tissue may be of enduring value and of importance for invasion metastasis formation and trcatrnent of primary and metastatic tumors. In order to research the structure of microcirculation and circulation properties in the lung cancer tissue, we used the external car of the nude mice as a pattern of transparent mnicrocirculation of human lung carcinoma. The vascular distribution and microcirculation structure was studied by transmission and scanning electron microscope and MCTV-system. Open sinusoid and atypical thin-walled capillaries, which consist of cndothclial cells of single layers with the large gaps were found by electron microscopy in the human lung cancer tissue in nude mice. There are many red cells and platelets from the lumen of the open capillaries to space between neighboured cancer cells. The interval is one of the traffic path ways of compositive microcirculation in the human lung cancer tissue. It is suggested that cancer cells seem to swim in the blood pool of open microcirculation in the human lung cancer tissue.