正常人汉语句子事件相关电位N400的研究

目的研究汉语句子结尾词匹配与不匹配事件相关电位N400的变化,探讨正常人汉语句子N400的特征。方法对15名21~36岁右利手健康受试者,进行汉语正常句子结尾匹配词(匹配)与句子结尾歧义词(不匹配)N400的研究。结果受试者对句子结尾词匹配与不匹配的N400成分在潜伏期及波幅有显著性差异(P<0.05),句子不匹配结尾词的N400潜伏期较长,N400波幅高。N400广泛分布于脑部各区,左侧波幅偏高。结论汉语句子结尾字匹配与不匹配的N400与字词认知中的语义密切相关,可作为一个有临床价值的认知电位而用于临床多种伴有语言障碍疾病的评估。

N400 event-related potentials of semantic matching of sentence-ending words in healthy Chinese subjects

Objective To investigate of changes in N 400 event-related potentials (ERPs) in recognition of semantically matching ending words of Chinese sentences for analysis of the characteristics of Chinese sentence N 400 in healthy subjects. Methods Fifteen healthy right-handed volunteers aging from 21 to 36 years old were tested for N 400 when they were asked to read Chinese sentences with semantically matching or mismatching ending words. Results Significant differences were found in N 400 latencies and amplitudes when the subjects were reading the carefully designed Chinese sentences (P<0.05). The latencies of N 400 were delayed and the amplitudes increased when the subjects were confronted with mismatching ending words, in the event of which N 400 amplitudes were higher in the left than in the right hemisphere of the brain. Conclusions N 400 in Chinese sentence-ending word matching test is close by related to the semantic context of the word recognition, and possesses clinically valuable recognition potential for assessing language disorders.