| 两个血浆-效应室平衡速率常数值用于靶控丙泊酚效应位浓度对血流动力学的影响 |
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| 引用本文： | 牛静,俞青,张马忠,王珊娟.两个血浆-效应室平衡速率常数值用于靶控丙泊酚效应位浓度对血流动力学的影响[J].上海医学,2009,32(1). |
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| 作者姓名： | 牛静 俞青 张马忠 王珊娟 |
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| 作者单位： | 上海交通大学医学院附属仁济医院麻醉科,200001 |
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| 摘 要： | 目的 比较听觉诱发电位指数和双频指数监测计算的血浆-效应室平衡速率常数(keO)应用于控制效应位浓度输注系统对血流动力学的影响,以评价其临床应用的安全性.方法 85例不用术前药的患者分为TP组(39例)、TE1组(23例)和TE2组(23例),TP组靶控血浆浓度,TE1组和TE2组分别应用keO=0.62/min和1.83/min的靶控效应室浓度,记录血压、心率和患者意识消失的时间.结果 TP组的意识消失的时间为75 s,显著长于TE1和TE2组的40 s(P值均＜0.05).3组间收缩压降低的最大幅度、达到最大降幅的时间以及心率变化的差异均无统计学意义(P值均＞0.05).结论 相对于靶控血浆浓度,靶控效应室浓度缩短了达到意识消失的时间.同时不会增加血压降低的幅度.
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| 关 键 词： | 麻醉药 丙泊酚 药效动力学 血浆-效应室平衡速率常数 |
Effect of target-controlled effect-site concentration of propofol on hemodynamics |
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| NIU Jing,YU Qing,ZHANG Mazhong,WANG Shanjuon.Effect of target-controlled effect-site concentration of propofol on hemodynamics[J].Shanghai Medical Journal,2009,32(1). |
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| Authors: | NIU Jing YU Qing ZHANG Mazhong WANG Shanjuon |
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| Institution: | NIU Jing,YU Qing,ZHANG Mazhong,WANG Shanjuan.Department of Anesthesiology,Shanghai Renji Hosital,Shanghai Jiaotong University School of Medicine,Shanghai 200001,China |
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| Abstract: | Objective To compare the effects of target-controlled plasma concentration and effect-site concentrations(2 ke0s)of propofol on hemodynamics in Chinese patients.Methods Eighty-five patients were divided to 3 groups:TP(TCI device controlled the plasma concentration,n=39),TE1 and TE2 groups(TCI device controlled the effect-site concentration with the values of ke0 0.62/min,and 1.83/min,respectively,n=23 each).Blood pressure,heart rate and the time of loss of consciousness(LOC)were an recorded.Results The time... |
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| Keywords: | Anaesthetics Propofol Pharmacodynamic Plasma effect site equilibration rate constant |
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